Members of the astacin family of metalloproteinases such as human bone morphogenetic protein 1 (BMP‐1) have previously been linked to cell differentiation and pattern formation during development through a proposed role in the activation of latent growth factors of the TGF‐β superfamily. Recent finding(1) indicate that BMP‐1 is identical to pro‐collagen C‐proteinase, which is a metalloproteinase involved in extracellular matrix (ECM) formation. This observation suggests that a functional link may exist between astacin metalloproteinases, growth factors and cell differentiation and pattern (...) formation during development. Taken together, current studies indicate that BMP‐1 and possibly other astacin metalloproteinases are multifunctional enzymes that act directly on growth factors and the ECM. In combination, these dual actions would have profound effects on developmental processes. (shrink)

The body wall of Hydra is organized as an epithelial bilayer with an intervening extracellular matrix (ECM). Molecular and biochemical analyses of Hydra ECM have established that it contains components similar to those seen in more complicated vertebrates such as human. In terms of biophysical parameters, Hydra ECM is highly flexible; a property that facilitates continuous movements along the organism's longitudinal and radial axis. A more rigid ECM, as in vertebrates, would not be compatible with this degree of movement. The (...) flexible nature of Hydra ECM can now be explained in part by the unique structure of the organism's collagens. Interestingly, some aspects of the structural features of Hydra collagens mimic what is seen in Ehlers‐Danlos syndrome, an inherited condition in humans that results in an abnormally flexible ECM that can be debilitating in extreme cases. This review will focus on structure–function relationships of the ECM of Hydra. BioEssays 23:716–724, 2001. © 2001 John Wiley & Sons, Inc. (shrink)

Justice Stephen J. Field was the champion of a form of liberalism often said to be especially friendly to capitalism, the approach to the Constitution traditionally identified with “Lochnerism,” i.e., a laissez-faire oriented judicial activism. More recently a form of judicial revisionism has arisen, challenging the accepted descriptions of “Lochnerism” and of Field's jurisprudence. This article is an attempt to extend the revisionist approach by arriving at a more satisfactory understanding of the grounding of Field's jurisprudence in the natural rights (...) philosophy. Field, it turns out, orienting around natural rights, was not so unambiguously friendly to capitalism as previous generations of scholars maintained, but his approach is surely friendlier than the constitutional theories that have replaced natural rights since Field's day. (shrink)

What is truth? Michael Lynch defends a bold new answer to this question. Traditional theories of truth hold that truth has only a single uniform nature. All truths are true in the same way. More recent deflationary theories claim that truth has no nature at all; the concept of truth is of no real philosophical importance. In this concise and clearly written book, Lynch argues that we should reject both these extremes and hold that truth is a functional property. (...) To understand truth we must understand what it does, its function in our cognitive economy. Once we understand that, we'll see that this function can be performed in more than one way. And that in turn opens the door to an appealing pluralism: beliefs about the concrete physical world needn't be true in the same way as our thoughts about matters -- like morality -- where the human stain is deepest. (shrink)

In Natural Rights and the New Republicanism, Michael Zuckert proposes a new view of the political philosophy that lay behind the founding of the United States.

An investigation into the way in which information technology has shaped how and what we know, from "Google-knowing" to privacy and social media.

In this engaging and spirited text, Michael Lynch argues that truth does matter, in both our personal and political lives. He explains that the growing cynicism over truth stems in large part from our confusion over what truth is.

I shall argue that the question ‘Can we speak literally of God?’ is fundamentally an epistemological question concerning whether we can know that God exists. If and only if we can know that God can exist can we know that we can speak literally of God.

Through various applications of the ‘deep structure’ of moral and religious reasoning, I have sought to illustrate the value of a morally informed approach in helping us to understand the complexity of religious thought and practice…religions are primarily moved by rational moral concerns and…ethical theory provides the single most powerful methodology for understanding religious belief. Ronald Green, Religion and Moral Reason.

In The Existence of God Richard Swinburne argues that ‘if there is a God, any experience which seems to be of God, will be genuine – will be of God.’ On the face of it this claim of the essential veridicality of any religious experience, given the existence of God, is incredible. Consider what is being claimed by looking at a particularly dramatic example – but one that is well within the purview of Swinburne's claim. The ‘Yorkshire Ripper’ who murdered (...) at least thirteen women, claimed to hear voices telling him to kill. He took these voices to be divine. While it is easy enough to suspect the killer's sanity, it is not so easy to doubt his sincerity. Yet since Swinburne claims that God probably exists, he is committed to the view that the Ripper had a series of genuine religious experiences – so much for the arduous preparations sometime taken as necessary for a ‘vision’ of God. (shrink)

Two theses are central to foundationalism. First, the foundationalist claims that there is a class of propositions, a class of empirical contingent beliefs, that are ‘immediately justified’. Alternatively, one can describe these beliefs as ‘self–evident’, ‘non–inferentially justified’, or ‘self–warranted’, though these are not always regarded as entailing one another. The justification or epistemic warrant for these beliefs is not derived from other justified beliefs through inductive evidential support or deductive methods of inference. These ‘basic beliefs’ constitute the foundations of empirical (...) knowledge. One can give a reason for the justification of a basic belief even though the justification for that belief is not based on other beliefs. Thus, according to Chisholm, if asked what one's justification was for thinking that one knew, presently, that one is thinking about a city one takes to be Albuquerque, one could simply say ‘what justifies me…is simply the fact that I am thinking about a city I take to be Albuquerque’. (shrink)

Know-it-All Society is about how we form and maintain our political convictions, and the ways in which political ideologies, human psychology and technology conspire to make our society more dogmatic, less intellectually humble and ultimately less democratic.

Philosophers often distinguish in some way between two senses of life's meaning. Paul Edwards terms these a ‘cosmic’ and ‘terrestrial’ sense. The cosmic sense is that of an overall purpose of which our lives are a part and in terms of which our lives must be understood and our purposes and interests arranged. This overall purpose is often identified with God's divine scheme, but the two need not necessarily be equated. The terrestrial sense of meaning is the meaning people find (...) in their own lives apart from the place of their lives in any ultimate end or context. (shrink)

A Choice Outstanding Academic Title for 1999 Academic debates about pluralism and truth have become increasingly polarized in recent years. One side embraces extreme relativism, deeming any talk of objective truth as philosophically naïve. The opposition, frequently arguing that any sort of relativism leads to nihilism, insists on an objective notion of truth according to which there is only one true story of the world. Both sides agree that there is no middle path. In Truth in Context, Michael Lynch (...) argues that there is a middle path, one where metaphysical pluralism is consistent with a robust realism about truth. Drawing on the work of Hilary Putnam, W.V.O. Quine, and Ludwig Wittgenstein, among others, Lynch develops an original version of metaphysical pluralism, which he calls relativistic Kantianism. He argues that one can take facts and propositions as relative without implying that our ordinary concept of truth is a relative, epistemic, or "soft" concept. The truths may be relative, but our concept of truth need not be. (shrink)

Those who in the past tended to say that being is a genus, coupled their assertion with the belief that the genus is univocal, thus making being univocal—a position which can easily be overturned. Others failed to distinguish between being as meaning essence, and so divisible into the ten categories, and being as meaning existence. The consequence was that they restricted the Divine Being to a genus of being, thereby denying God’s transcendence. As far as I know, the theory which (...) combines the two doctrines that the genus is analogical and that the being which is held to be a genus is only essence, has never been propounded. It merits investigation. (shrink)

This paper contributes to the (re-)conceptualisation of responsible innovation by proposing an evolutionary economic approach that focuses on the role of consumers in the innovation process. After a discussion of the philosophical foundations and ethical implications of this approach, which bears an explanatory potential that has not been adequately considered in previous discussions of responsible innovation, we present a first step towards capturing the important but often neglected role of consumers in innovation processes (including responsible innovation): We propose an agent-based (...) model that incorporates a multidimensional space of characteristics in which new products or services are represented by more than the mere aspect of price and quality. Instead, innovations are denoted by a large set of characteristics, including also negative or harmful ones. The model is used to illustrate that consumers’ heterogeneity and bounded rationality – even if considered in a simple manner – indeed play a crucial role in the creation and diffusion of responsible innovation which can and should be used for further work in this field and for possible extensions of the model. (shrink)

These essays center around two questions: Does truth have an underlying nature? And if so, what sort of nature does it have?

After reflecting on his own undergraduate education, when the study of Newman’s The Idea of a University led to a transformation of his view of education and even life itself, Michael Krom discusses—in the contemplative spirit that Newman contended to be the purpose of education—how Newman’s Idea can be taught in a way so that today’s students are enlivened with the universal call to Truth and Holiness.

Are most people sincere when they share misinformation and conspiracies online? This question, while natural and important, is difficult to answer for obvious reasons. But it also applies poorly to one of the main vehicles for misinformation—memes. And it can be ambiguous; as a result, we should be mindful of two distinctions. First, a distinction between belief and a related propositional attitude, commitment. And second, the distinction between the propositional content of an attitude and what I will call its political (...) meaning. I will suggest that these distinctions not only can help us understand how we communicate online, but they also suggest a lesson about what we should be focusing on when fighting misinformation. (shrink)

Let us follow Robert Oakes in describing a self-authenticating experience of God as one that ‘would have the epistemic uniqueness of guaranteeing –all by itself – its veridicality to the person who had it.’ The idea that there could be self-authenticating experiences of God has been criticized often in recent years. It seems that the only experiences that could be self-authenticating are those about one's own current psychological states. Nevertheless, the individual who claims to have such an experience of God (...) is clearly using ‘experience’ in such a way as to suppose that one's experience of God is logically independent of the existence of God, but still self-authenticating. (shrink)

Why does the paradox play such a crucial role in Kierkegaard's notion of truth as subjectivity? Richard Schacht explains it as follows: Eternal happiness is possible for a man only if it is possible for him to relate himself to God. A man, however, is a being who exists in time; and it would not be possible for such a being to enter into a ‘God-relationship’ if God had not also at some point existed in time. Through the ‘leap of (...) faith’ in which one affirms the proposition that God did exist in time, one is able to enter a ‘God-relationship’ and thereby attains ‘an eternal happiness’. (shrink)

This philosophical analysis of the phenomenon of racism brings together some of the most influential analytic philosophers writing on racism today. The introduction by Tamas Pataki outlines the historical and thematic development of conceptions of race and racism, and locates the following essays against the backdrop of contemporary reactions to that development. While the framework is primarily analytic, the volume also includes essays deeply informed by psychoanalysis, phenomenology, and feminist and social theory. The fourteen chapters in this collection address three (...) interrelated questions: What is racism? What are the causes of racism? and What are the moral and political implications of racism? Although their approaches are wide ranging, the contributors to Racism in Mind broadly endorse a psychological-characterological approach to the understanding of many aspects of racism. (shrink)

Minimalists generally see themselves as engaged in a descriptive project. They maintain that they can explain everything we want to say about truth without appealing to anything other than the T-schema, i.e., the idea that the proposition that p is true iff p. I argue that despite recent claims to the contrary, minimalists cannot explain one important belief many people have about truth, namely, that truth is good. If that is so, then minimalism, and possibly deflationism as a whole, must (...) be rejected or recast as a profoundly revisionary project. (shrink)

At the heart of this essay lies the problem of Christian universals.Sin-talk is arguably Christian theology’s primary contribution to any account of the human condition. Fashionable or unfashionabl...